Frequently asked questions

Whole genome sequencing (WGS) reads every single nucleotide in your DNA. Unlike targeted genetic tests that examine a handful of genes, WGS reads all 3.2 billion base pairs of your genome. This includes every gene, every regulatory region, and every intergenic sequence. The result is the most complete genetic picture available today, identifying 4.6 to 5 million variants unique to you.

Consumer DNA tests like 23andMe use genotyping chips that read approximately 600,000 to 700,000 pre-selected positions in your DNA, which is less than 0.1% of your genome. Dante Labs sequences your entire genome at 30X clinical-grade depth, reading all 3.2 billion base pairs and identifying 4.6 to 5 million variants. The difference is not incremental. It is the difference between skimming the table of contents and reading the entire book.

30X coverage means that, on average, every position in your genome is read 30 times. This level of redundancy is the clinical standard for diagnostic-grade accuracy. It ensures that identified variants are real, not sequencing artifacts. Lower coverage (e.g. 1X or 4X) is cheaper but produces significantly less reliable results, particularly for rare variants that matter most clinically.

Your results include 200+ clinical-grade reports covering hereditary disease risk, pharmacogenomics (how you metabolize medications), carrier status, wellness and nutrition, ancestry, and specialized condition panels for cardiac, oncology, neurological, and rare disease categories. Reports are physician-ready and organized by clinical category in your Genome Manager portal.

Yes. Your DNA does not change, but the science that interprets it does. As new variant-disease associations are validated and published, we apply those discoveries to your existing genome data and update your reports automatically. You sequence once and receive updated insights for life. 22% of initially negative findings have received new clinically significant results within 3 years of re-analysis.

Order your test online. We ship a collection kit to your home within 48 hours. Collect your saliva sample following the included instructions (takes about 5 minutes), register your kit online, and send it back using the prepaid return packaging. Your results will be available in your Genome Manager portal in 6 to 8 weeks.

A simple saliva sample. No needles, no clinic visit, no blood draw required. The collection kit includes everything you need and takes approximately 5 minutes to complete at home. For the Prevention Program's RNA profile, a small blood sample may be required.

No. You can order your Dante Labs whole genome test directly without a doctor's referral. Your results are designed to be shared with your physician or healthcare provider, and our reports are formatted for clinical use. If you would like a physician to order on your behalf, that option is also available.

Your sample is processed in our CLIA-certified, ISO 15189-accredited laboratory. We operate labs in the US and EU, both meeting the highest standards for clinical genomics. The lab your sample is routed to depends on your geographic location, ensuring fastest turnaround and compliance with local data protection regulations.

All results are delivered to your Genome Manager, a secure online portal accessible from any device. You will receive a notification when your reports are ready. Reports are organized by clinical category and can be downloaded as PDFs for sharing with your healthcare provider.

Genome Manager is your personal genomics portal. It is where all your reports, raw data, and AI Genome Chat live. You can browse reports by category, search for specific genes or conditions, download raw data files (BAM, VCF, FASTQ), and ask questions about your results in plain language using AI Genome Chat. It is designed for both you and your physician.

Yes. Reports are specifically formatted for clinical use. You can download individual reports or your complete results as PDFs and share them directly with your physician, genetic counselor, or any healthcare provider. Many of our users bring their Dante Labs reports to specialist consultations, where they have contributed to diagnosis and treatment decisions.

If your results identify a clinically significant variant, your report will include the clinical classification (following ACMG guidelines), the associated condition, and recommendations for next steps. We strongly recommend discussing significant findings with a qualified healthcare provider or genetic counselor who can interpret the results within the full context of your medical history and guide appropriate follow-up.

Yes. Dante Labs whole genome sequencing is performed at 30X clinical-grade depth in CLIA-certified, ISO 15189-accredited laboratories. Variants are classified following ACMG (American College of Medical Genetics) guidelines. Our reports are used by physicians and specialists worldwide for clinical decision-making, including complex diagnostic cases at major hospitals.

Our laboratories hold CLIA certification, CAP accreditation, and ISO 15189 medical laboratory accreditation. We also maintain ISO 9001 (quality management), ISO 13485 (medical devices), and operate under GDPR and HIPAA data protection standards. These certifications represent the highest tier of laboratory quality and compliance in clinical genomics.

Yes. Physicians can order Dante Labs whole genome sequencing directly for their patients. We offer physician ordering portals with additional clinical tools, priority processing, and direct support for clinical integration. Contact us at hello@dantelabs.com for physician ordering information.

Absolutely. Whole genome sequencing is designed to complement, not replace, other clinical investigations. Your genomic data can inform and be informed by imaging, blood work, biopsies, and other diagnostic procedures. Many physicians use Dante Labs reports alongside existing clinical data to build a more complete diagnostic picture, particularly in complex or unresolved cases.

You do. Your genomic data belongs to you, fully and without exception. We process and store it on your behalf, but ownership never transfers to Dante Labs. You can download your complete raw data files (BAM, VCF, FASTQ) at any time, and you can request full deletion of your data from our systems whenever you choose.

No. Your genomic data is never sold or shared with third parties, pharmaceutical companies, insurance providers, or research institutions without your explicit, informed consent. This is not a marketing promise. It is enforced by GDPR regulation, which governs our laboratory operations.

After your sample has been sequenced and your data extracted, the physical sample is destroyed in accordance with our laboratory protocols. We do not retain biological material beyond what is necessary for quality assurance during the sequencing process.

Yes. Our Italian laboratory operates under GDPR, the most stringent data protection regulation in the world. Our US operations comply with HIPAA. Your genomic data is stored in isolated, encrypted environments with identifiable information separated from genetic data at every layer. You have the right to access, export, and delete your data at any time.

Kits ship within 48 hours of your order. Domestic delivery typically takes 3 to 7 business days depending on your location. Express shipping options are available at checkout.

Yes. We ship to over 100 countries worldwide. International shipping times vary by destination but typically range from 5 to 14 business days. Prepaid return packaging is included with every kit, regardless of location.

Results are typically delivered within 6 to 8 weeks from the time your sample arrives at our laboratory. You will receive email notifications at each stage: sample received, sequencing in progress, and results ready. Priority processing is available with select plans for faster turnaround.

The Dante Labs Whole Genome Test starts from $449 (EU: from €399). The Prevention Program, which combines genome sequencing with RNA profiling and ongoing monitoring, starts from $999. All plans are HSA/FSA eligible and BNPL (buy now, pay later) options are available at checkout.

You can reach us at hello@dantelabs.com. Our support team is available to help with questions about ordering, sample collection, results, and clinical use. For physician inquiries, please include your practice information in your message.